HitPredict

Interactor 1: ADA10 (O14672)
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Gene: ADAM10

Interactor 2: PACN2 (Q9UNF0)
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Gene: PACSIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036101
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0043231 - intracellular membrane-bounded organelle GO:0070062 - extracellular exosome and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 748 Hs			1 486
+	Hs
		152327 ADA10_HUMAN (12-748): 0: 717: 100.00		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Hs
		152352 ADA10_HUMAN (12-748): 0: 717: 100.00		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		152206 ADA10_HUMAN (12-748): 0: 717: 100.00		PPIP1_HUMAN (9-485): 2.02e-55: 192: 18.67
+	Hs
		152280 ADA10_HUMAN (12-748): 0: 717: 100.00		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		152211 ADA10_HUMAN (12-748): 0: 717: 100.00		GAS7_HUMAN (427-486): 7.06e-09: 59.9: 34.43
+	Hs
		944531 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		944521 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Mm
		1142117 ADAM9_MOUSE (35-644): 1.57e-142: 441: 21.50		PACN3_MOUSE (6-485): 3.11e-69: 228: 43.54
+	Hs
		1034743 ADAM9_HUMAN (35-644): 7.75e-145: 446: 21.18		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		944529 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		197625 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		1034780 ADA15_HUMAN (54-625): 7.02e-117: 374: 20.20		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		941711 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		CIP4_HUMAN (12-465): 9.47e-47: 173: 15.03
+	Hs
		941717 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		FNBP1_HUMAN (12-397): 7.86e-42: 159: 15.01
+	Mm
		292358 ADA15_MOUSE (58-605): 6.56e-91: 305: 20.99		PACN3_MOUSE (6-485): 3.11e-69: 228: 43.54
+	Hs
		1356560 ADA18_HUMAN (41-597): 9.24e-80: 272: 20.83		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		941713 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		FBP1L_HUMAN (300-482): 7.32e-09: 60.2: 19.05
+	Hs
		1132434 ADA19_HUMAN (62-656): 2.19e-116: 375: 19.71		FBP1L_HUMAN (300-482): 7.32e-09: 60.2: 19.05