HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: LHX2 (P50458)
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)
Gene: LHX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 406
+	Hs
		152612 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63
+	Hs
		152657 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX8_HUMAN (115-394): 4.48e-35: 134: 23.84
+	Hs
		152677 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX4_HUMAN (34-107): 2.07e-11: 67.1: 23.68
+	Hs
		152696 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX3_HUMAN (27-113): 1e-09: 61.7: 22.47
+	Hs
		839827 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX2_HUMAN (1-406): 2.55e-97: 298: 100.00
+	Hs
		839806 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX2_HUMAN (1-406): 2.55e-97: 298: 100.00
+	Hs
		822681 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63
+	Hs
		822665 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX1_HUMAN (53-404): 1.01e-49: 174: 26.63
+	Hs
		903721 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		LMO4_HUMAN (33-186): 6.88e-53: 175: 37.58
+	Hs
		1296441 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX6_HUMAN (111-368): 2.79e-21: 96.4: 21.32
+	Hs
		1281184 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX4_HUMAN (34-107): 2.07e-11: 67.1: 23.68
+	Hs
		1281166 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX4_HUMAN (34-107): 2.07e-11: 67.1: 23.68
+	Hs
		1334137 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX3_HUMAN (27-113): 1e-09: 61.7: 22.47
+	Hs
		1296429 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX3_HUMAN (27-113): 1e-09: 61.7: 22.47
+	Hs
		203710 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		LHX8_HUMAN (115-394): 4.48e-35: 134: 23.84
+	Hs
		1078873 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		LMO3_HUMAN (53-108): 5.21e-10: 59.2: 28.07
+	Dm
		114766 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		M9PD53_DROME (111-346): 8.42e-29: 120: 21.19
+	Dm
		112563 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		M9NCY1_DROME (111-346): 8.93e-29: 118: 21.19
+	Dm
		1368403 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		Q9VJ37_DROME (35-106): 1.42e-09: 61.7: 25.68
+	Dm
		954993 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		P92031_DROME (35-106): 1.51e-09: 61.7: 25.68