HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 2035
+	Hs
		152704 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Hs
		848225 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		848199 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		848317 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		165649 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		848319 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		1235458 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LZTR1_HUMAN (17-461): 2.92e-79: 283: 16.67
+	Hs
		1080502 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		KLDC2_HUMAN (5-403): 2.43e-73: 253: 20.92
+	Hs
		203776 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		KLDC3_HUMAN (68-425): 9.22e-58: 207: 21.14
+	Hs
		203817 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		KLH20_HUMAN (2-263): 2.49e-55: 206: 14.39
+	Dm
		785649 EZ_DROME (5224-5516): 2.4e-89: 313: 18.75		Q9W3D5_DROME (137-414): 1.2e-40: 158: 22.87
+	Dm
		1129077 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		HCF_DROME (948-2031): 9.87e-34: 144: 15.87
+	Dm
		1215702 TRR_DROME (6-219): 2.09e-41: 172: 21.96		HCF_DROME (948-2031): 9.87e-34: 144: 15.87
+	Hs
		1049288 DPF1_HUMAN (240-320): 4.65e-15: 82.8: 46.43		KEAP1_HUMAN (2-262): 1.96e-59: 219: 17.11
+	Hs
		975356 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Hs
		1357298 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Hs
		165746 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Hs
		1357739 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Zm
		35425 A0A1D6LLI6_MAIZE (5386-5515): 1.83e-16: 89.7: 35.34		A0A1D6PPA8_MAIZE (105-562): 2.75e-33: 141: 15.91
+	Dm
		113976 M9PB30_DROME (4122-4751): 2.37e-12: 76.7: 14.20		M9PB30_DROME (1365-2025): 2.64e-17: 91.4: 9.45