HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.990

Property	Details
Experiments	27563068, 30604749, 24981860, 32350066, 17925232, 16603732, 22665483, 24491801, 26186194, 24788516, 28514442, 27705803, 30107592, 33022573, 33961781, 34933446, 33472061, 36395886, 15960974, 22266653 and 4 others more... 22689669, 17500065, 17178841, 15960975
Identification Methods	pull down, affinity chromatography technology, unspecified method, x-ray crystallography, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0042393 - histone binding GO:0042800 - histone H3K4 methyltransferase activity and 1 others more... GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 334
+	Hs
		152663 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5B_HUMAN (3-198): 4.87e-59: 194: 30.10
+	Hs
		152678 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		903444 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		209441 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Dm
		1129076 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		WDS_DROME (3-290): 7.53e-92: 279: 31.21
+	Hs
		1281314 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		903149 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903604 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	At
		1319861 ATX1_ARATH (5318-5537): 4.41e-68: 255: 33.20		WDR5A_ARATH (2-241): 2.46e-75: 236: 27.82
+	Hs
		165657 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903609 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		203735 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		DAW1_HUMAN (144-333): 8.06e-44: 157: 30.69
+	Sc
		744551 SET1_YEAST (5160-5537): 1.76e-83: 303: 27.25		SWD3_YEAST (29-330): 8.4e-45: 157: 34.47
+	Hs
		1080207 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Sp
		195053 SET1_SCHPO (5320-5537): 5.36e-66: 247: 34.30		SWD3_SCHPO (166-330): 1.84e-12: 69.3: 30.30
+	Hs
		975303 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		975304 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		1288387 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		1288292 NSD3_HUMAN (175-329): 6.17e-23: 111: 17.79		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		331862 NSD2_HUMAN (175-334): 9.23e-17: 91: 17.37		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29