HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36598580
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 136
+	Hs
		152661 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935251 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086320 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		935126 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086279 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952633 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		952553 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174632 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Mm
		952777 EHMT2_MOUSE (4917-5533): 2.26e-101: 361: 18.29		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		828381 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Mm
		952754 Q6AXH7_MOUSE (5194-5519): 2.35e-94: 327: 19.48		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Mm
		952747 EZH2_MOUSE (5194-5519): 1.01e-92: 322: 19.48		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		934804 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1079993 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952363 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		203659 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		203664 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Dm
		356072 EZ_DROME (5224-5516): 2.4e-89: 313: 18.75		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Hs
		1080038 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		203706 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		H37_HUMAN (1-136): 5.62e-59: 180: 97.06