Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 27634302
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~preSET_CXC, SET~SET
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0008284 - positive regulation of cell population proliferation
GO:0031507 - heterochromatin formation
and 1 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 5537
Hs

1 746
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Last updated: 15 Jul 2024