HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: SRRM1 (Q8IYB3)
Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
Gene: SRRM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16159877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 904
+	Hs
		152667 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		1295406 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		CHAP1_HUMAN (463-892): 8.67e-10: 64.5: 14.85
+	Hs
		1295391 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		CHAP1_HUMAN (463-892): 8.67e-10: 64.5: 14.85
+	Hs
		132346 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		CAC1A_HUMAN (94-637): 2.17e-09: 63.6: 14.46
+	Hs
		1080420 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		CHD7_HUMAN (120-837): 5.02e-29: 127: 10.84
+	Hs
		203228 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		SYNJ1_HUMAN (546-902): 8.17e-11: 68.4: 13.82
+	Hs
		554310 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		MUC1_HUMAN (164-720): 6.29e-11: 68.6: 15.61
+	Hs
		1080127 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		152654 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		203726 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		Q86V38_HUMAN (108-815): 1.29e-09: 64.2: 10.99
+	Mm
		1351630 PCLO_MOUSE (3974-4802): 1.38e-21: 107: 11.89		PCLO_MOUSE (84-904): 4.87e-24: 111: 9.78
+	Hs
		975285 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Ce
		136802 UNC89_CAEEL (351-1153): 2.3e-25: 119: 13.28		UNC22_CAEEL (254-904): 3.28e-14: 79.8: 15.42
+	Hs
		152630 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		1243852 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		152700 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		165699 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		1243853 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		KMT2C_HUMAN (390-904): 1.47e-09: 64.6: 11.65
+	Hs
		152553 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32
+	Hs
		152701 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		KMT2D_HUMAN (365-903): 9.97e-09: 61.9: 12.32