HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	32350066, 36395886
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 707
+	Hs
		152622 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		152663 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5B_HUMAN (570-706): 6.06e-25: 108: 23.74
+	Hs
		1281314 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		1080207 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		975303 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		903444 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Dm
		1370339 Q9VLS7_DROME (668-1245): 4.42e-11: 72.2: 14.46		FBXW7_DROME (142-705): 3.41e-131: 421: 66.33
+	At
		1319861 ATX1_ARATH (5318-5537): 4.41e-68: 255: 33.20		WDR5A_ARATH (236-526): 7.21e-60: 206: 20.66
+	Dm
		1129076 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		WDS_DROME (570-706): 5.69e-27: 115: 23.02
+	Hs
		1080496 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		1080462 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Mm
		1225220 MYO15_MOUSE (4032-4304): 4.42e-10: 69.3: 17.30		AHI1_MOUSE (119-704): 3.18e-91: 308: 17.70
+	Hs
		203735 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		DAW1_HUMAN (240-366): 3.95e-10: 64.3: 6.15
+	Hs
		903149 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903604 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		165657 SET1A_HUMAN (5396-5537): 8.48e-22: 107: 46.15		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903609 SET1B_HUMAN (5404-5537): 1.82e-21: 106: 48.89		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Mm
		903669 KMT2C_MOUSE (1364-1947): 5.56e-10: 69: 16.64		WDR5_MOUSE (570-706): 2.64e-27: 115: 23.02
+	Hs
		903374 KMT2C_HUMAN (223-338): 3.09e-09: 66.3: 40.34		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		1317584 SETD2_HUMAN (5389-5536): 1.87e-15: 87: 34.23		NLE1_HUMAN (269-366): 5.18e-09: 61.2: 13.86