HitPredict

Interactor 1: RGPD8 (O14715)
RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)
Gene: RGPD8

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Rab_bind~Ras, Ran_BP1~Ras
Common GO terms	GO:0005643 - nuclear pore GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1765 Hs			1 216
+	Hs
		919236 RGPD5_HUMAN (1-1765): 0: 2148: 99.49		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		483422 RGPD2_HUMAN (1-1760): 0: 2100: 93.41		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		63882 RGPD3_HUMAN (1-1757): 0: 2095: 95.68		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919141 RGPD4_HUMAN (1-1757): 0: 2093: 95.05		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		483392 RGPD1_HUMAN (26-1760): 0: 2084: 93.83		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		914195 GCC2_HUMAN (1003-1765): 2.46e-65: 248: 26.58		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Sc
		698833 NU159_YEAST (750-1707): 6.12e-57: 220: 12.02		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Ce
		184992 Q21021_CAEEL (921-1340): 1.1e-28: 127: 17.91		RAN_CAEEL (3-205): 3.44e-97: 283: 88.18
+	At
		784994 RBP1A_ARATH (1010-1239): 9.84e-31: 123: 26.96		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Sc
		698847 YRB1_YEAST (998-1173): 5.83e-39: 146: 43.96		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		834710 RBP2_HUMAN (866-1488): 4.76e-37: 155: 21.81		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698835 YRB2_YEAST (888-1165): 2.36e-35: 140: 18.49		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sp
		660086 RANG_SCHPO (1273-1469): 2.66e-34: 133: 31.34		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	At
		785000 RBP1A_ARATH (1010-1239): 9.84e-31: 123: 26.96		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Sc
		691616 NUP2_YEAST (879-1468): 1.38e-29: 129: 13.46		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		919306 NUP50_HUMAN (1158-1466): 9.52e-33: 136: 19.55		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		1210455 RBP1A_ARATH (1010-1239): 9.84e-31: 123: 26.96		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Hs
		919269 RANB3_HUMAN (936-1518): 1.54e-26: 118: 15.13		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		591920 GCC2_HUMAN (1003-1765): 2.46e-65: 248: 26.58		RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57
+	Hs
		845340 NUP50_HUMAN (1158-1466): 9.52e-33: 136: 19.55		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13