HitPredict

Interactor 1: APAF (O14727)
Apoptotic protease-activating factor 1 (APAF-1)
Gene: APAF1

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031072 - heat shock protein binding GO:0042981 - regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1248 Hs			1 465
+	Hs
		227292 TBL3_HUMAN (893-1248): 1.24e-52: 201: 13.06		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226026 WDR1_HUMAN (511-911): 4.69e-45: 175: 14.41		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228745 GBB4_HUMAN (994-1248): 9.28e-41: 156: 14.29		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227054 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226765 LIS1_HUMAN (426-687): 1.05e-32: 134: 15.60		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228868 NLE1_HUMAN (488-642): 5.63e-18: 90.8: 15.48		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		229068 WDR3_HUMAN (1139-1246): 7.45e-15: 81.9: 18.18		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228315 SNR40_HUMAN (698-1027): 2.23e-13: 75.1: 22.75		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	At
		1091856 RPP7_ARATH (123-561): 3.86e-95: 332: 16.16		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091862 RPP8_ARATH (67-550): 5.34e-96: 330: 16.83		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		473839 RP8L2_ARATH (2-454): 1.57e-94: 326: 17.07		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092405 DRL4_ARATH (126-454): 3.54e-93: 321: 20.11		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091858 DRL7_ARATH (13-518): 2.05e-92: 320: 17.85		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		1334930 GBB4_HUMAN (994-1248): 9.28e-41: 156: 14.29		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	Hs
		1219356 SNR40_HUMAN (698-1027): 2.23e-13: 75.1: 22.75		CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58
+	Hs
		476404 GBB4_HUMAN (994-1248): 9.28e-41: 156: 14.29		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475563 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476181 SNR40_HUMAN (698-1027): 2.23e-13: 75.1: 22.75		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092188 GPLPC_ARATH (879-1204): 5.81e-14: 76.6: 24.50		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091956 GPLPB_ARATH (969-1204): 2.64e-12: 71.6: 25.78		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17