HitPredict

Interactor 1: APAF (O14727)
Apoptotic protease-activating factor 1 (APAF-1)
Gene: APAF1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome GO:0097193 - intrinsic apoptotic signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1248 Hs			1 768
+	Hs
		152876 APAF_HUMAN (1-1248): 0: 987: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		254082 WDR1_HUMAN (511-911): 4.69e-45: 175: 14.41		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		903207 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042101 POC1B_HUMAN (425-642): 8.55e-20: 96.2: 11.21		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042655 NLE1_HUMAN (488-642): 5.63e-18: 90.8: 15.48		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1016274 TBL3_HUMAN (893-1248): 1.24e-52: 201: 13.06		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043234 GBB4_HUMAN (994-1248): 9.28e-41: 156: 14.29		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		560878 GBB3_HUMAN (578-825): 4.43e-39: 151: 18.65		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		245601 TBL1X_HUMAN (417-732): 1.55e-40: 160: 16.62		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903208 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		792982 LIS1_HUMAN (426-687): 1.05e-32: 134: 15.60		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		903209 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043114 POC1B_HUMAN (425-642): 8.55e-20: 96.2: 11.21		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043085 WDR5B_HUMAN (1157-1247): 3.41e-17: 86.2: 20.43		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043469 POC1B_HUMAN (425-642): 8.55e-20: 96.2: 11.21		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043157 SNR40_HUMAN (698-1027): 2.23e-13: 75.1: 22.75		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043441 WDR5B_HUMAN (1157-1247): 3.41e-17: 86.2: 20.43		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043509 SNR40_HUMAN (698-1027): 2.23e-13: 75.1: 22.75		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903206 WDR5_HUMAN (493-728): 4.38e-37: 145: 16.53		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		929443 RACK1_HUMAN (964-1207): 2.09e-10: 65.5: 25.29		CUL1_HUMAN (18-768): 0: 707: 30.57