HitPredict

Interactor 1: MP2K7 (O14733)
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
Gene: MAP2K7

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9614189
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 419 Hs			1 758
+	Hs
		496407 AKT1_HUMAN (81-415): 9.7e-138: 404: 19.59		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496408 AKT2_HUMAN (7-415): 9.54e-136: 399: 20.14		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496879 KPCE_HUMAN (21-416): 8.23e-130: 392: 20.69		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496248 KAPCA_HUMAN (109-412): 5.98e-128: 374: 20.97		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496307 KAPCB_HUMAN (109-412): 3e-127: 372: 20.32		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496305 KAPCG_HUMAN (109-417): 3.51e-126: 370: 21.07		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		581976 KAPCB_RAT (109-412): 9.16e-126: 369: 20.32		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94199 KAPCB_RAT (109-412): 9.16e-126: 369: 20.32		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		397198 KAPCA_MOUSE (110-412): 4.11e-127: 372: 20.39		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		497903 STK24_HUMAN (101-408): 1.8e-97: 300: 30.32		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		152597 AKT1_HUMAN (81-415): 9.7e-138: 404: 19.59		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		503261 KAPCA_HUMAN (109-412): 5.98e-128: 374: 20.97		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		503264 KAPCB_HUMAN (109-412): 3e-127: 372: 20.32		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		503263 KAPCG_HUMAN (109-417): 3.51e-126: 370: 21.07		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		496451 MP2K2_HUMAN (85-394): 3.44e-59: 199: 34.82		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		581989 MP2K1_RAT (85-416): 2.6e-61: 205: 34.48		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94211 MP2K1_RAT (85-416): 2.6e-61: 205: 34.48		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		497933 MP2K1_MOUSE (85-416): 4.56e-61: 204: 34.48		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Bt
		337290 KAPCA_BOVIN (109-412): 6.36e-127: 372: 20.97		TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00
+	Dm
		248389 O62602_DROME (106-399): 1.83e-100: 304: 44.44		Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96