HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 11152681, 10531356, 35046516, 22365833, 23071334, 11756452
Identification Methods affinity chromatography technology, two hybrid, biochemical, pull down, molecular sieving
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PRMT5~PRMT5_C, PRMT5~PRMT5_TIM, PRMT5_C~PRMT5_C, PRMT5_C~PRMT5_TIM
Common GO terms GO:0000387 - spliceosomal snRNP assembly
GO:0000785 - chromatin
GO:0002039 - p53 binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 34 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 637
Hs

1 637
+ Hs
+ Hs
+ Sp
+ Ce
+ Sc
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ At
+ At
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024