HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 637 Hs			1 465
+	Hs
		153518 ANM5_HUMAN (12-637): 0: 862: 100.00		ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82
+	Hs
		153545 ANM5_HUMAN (12-637): 0: 862: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091754 ANM15_ARATH (4-637): 0: 699: 45.22		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		228488 ANM1_HUMAN (289-610): 2.01e-110: 338: 16.81		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226986 ANM2_HUMAN (255-635): 4.28e-103: 321: 18.64		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226006 ANM3_HUMAN (293-610): 2.28e-96: 307: 16.92		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227951 CARM1_HUMAN (278-629): 4.57e-84: 277: 18.38		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		474972 ANM2_HUMAN (255-635): 4.28e-103: 321: 18.64		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	At
		1091739 ANM13_ARATH (268-602): 2.57e-89: 289: 18.68		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17