HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	21081503, 17974993
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0048026 - positive regulation of mRNA splicing, via spliceosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 637 Hs			1 710
+	Mm
		665762 ANM5_MOUSE (12-637): 0: 854: 97.76		PABP1_MOUSE (222-482): 5.43e-43: 167: 15.55
+	Hs
		582456 ANM1_HUMAN (289-610): 2.01e-110: 338: 16.81		NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00
+	Hs
		516666 ANM1_HUMAN (289-610): 2.01e-110: 338: 16.81		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Hs
		1031440 ANM1_HUMAN (289-610): 2.01e-110: 338: 16.81		PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88
+	Dm
		597078 CARM1_DROME (194-625): 2.98e-112: 348: 18.54		PABP_DROME (222-493): 3.93e-37: 149: 16.16
+	Dm
		597077 Q9VGW7_DROME (289-610): 2.91e-106: 327: 16.37		PABP_DROME (222-493): 3.93e-37: 149: 16.16
+	Hs
		516646 ANM6_HUMAN (320-610): 6.56e-88: 280: 18.53		PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55
+	Sp
		142141 ANM3_SCHPO (287-632): 2.07e-88: 287: 14.59		PABP_SCHPO (222-490): 1.21e-33: 139: 15.36