HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: RUXG (P62308)
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)
Gene: SNRPG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0034709 - methylosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 637 Hs			1 76
+	Hs
		153629 ANM5_HUMAN (12-637): 0: 862: 100.00		LSM6_HUMAN (3-75): 3.42e-27: 95.5: 26.03
+	Hs
		153635 ANM5_HUMAN (12-637): 0: 862: 100.00		RSMN_HUMAN (1-70): 1.26e-22: 88.2: 21.25
+	Hs
		153627 ANM5_HUMAN (12-637): 0: 862: 100.00		RUXF_HUMAN (5-73): 4.25e-24: 87.8: 24.64
+	Hs
		153553 ANM5_HUMAN (12-637): 0: 862: 100.00		RSMB_HUMAN (1-70): 6.75e-22: 86.3: 21.25
+	Mm
		646103 ANM5_MOUSE (12-637): 0: 854: 97.76		RSMB_MOUSE (1-70): 8.68e-22: 85.9: 21.25
+	Dm
		984931 CARM1_DROME (194-625): 2.98e-112: 348: 18.54		RSMB_DROME (1-70): 7.29e-22: 85.1: 21.25
+	Hs
		539123 ANM1_HUMAN (289-610): 2.01e-110: 338: 16.81		RSMB_HUMAN (1-70): 6.75e-22: 86.3: 21.25
+	Dm
		984930 Q9VGW7_DROME (289-610): 2.91e-106: 327: 16.37		RSMB_DROME (1-70): 7.29e-22: 85.1: 21.25