HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 18404153, 28977470, 21081503, 29518110, 11756452, 30392062, 33624332, 34326253, 35046516, 20951943, 22169276, 22365833, 23071334, 26763441, 30282801, 33020149, 25927346, 21316606, 12972618, 23892143 and 1 others

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Identification Methods two hybrid, affinity chromatography technology, x-ray crystallography, pull down, biochemical, cosedimentation in solution, molecular sieving, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PRMT5_TIM~WD40
Common GO terms GO:0000387 - spliceosomal snRNP assembly
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
and 4 others

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Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 637
Hs

1 342
+ Mm
+ Hs
+ Xl
+ Xl
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp

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Last updated: 15 Jul 2024