HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: KCTD5 (Q9NXV2)
BTB/POZ domain-containing protein KCTD5
Gene: KCTD5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 234
+	Hs
		153919 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		1075465 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		KCTD5_HUMAN (1-234): 6.84e-87: 258: 100.00
+	Hs
		1057222 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		1075429 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		KCD17_HUMAN (44-225): 3e-61: 196: 78.57
+	Hs
		153961 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		1075459 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		BACD3_HUMAN (20-224): 6.9e-57: 184: 22.82
+	Hs
		153935 NHRF1_HUMAN (1-358): 2.51e-82: 256: 100.00		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		1075479 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		1132926 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		KCTD5_HUMAN (1-234): 6.84e-87: 258: 100.00
+	Hs
		1075432 NHRF2_HUMAN (5-358): 2.98e-67: 216: 49.44		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		67923 PDZ1P_HUMAN (142-346): 3.81e-15: 77.8: 19.02		KCTD5_HUMAN (1-234): 6.84e-87: 258: 100.00
+	Hs
		1057225 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		67909 PDZ1P_HUMAN (142-346): 3.81e-15: 77.8: 19.02		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		1132909 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		KCD17_HUMAN (44-225): 3e-61: 196: 78.57
+	Hs
		1050021 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		KCNB2_HUMAN (16-214): 5.01e-42: 153: 19.25
+	Hs
		67915 PDZ1P_HUMAN (142-346): 3.81e-15: 77.8: 19.02		KCD17_HUMAN (44-225): 3e-61: 196: 78.57
+	Hs
		1050010 SCRIB_HUMAN (7-337): 1.45e-29: 122: 19.83		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		1132930 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		1132910 NHRF3_HUMAN (1-133): 3.86e-21: 96.3: 32.35		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		67916 PDZ1P_HUMAN (142-346): 3.81e-15: 77.8: 19.02		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54