HitPredict

Interactor 1: TERT (O14746)
Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
Gene: TERT

Interactor 2: PINX1 (Q96BK5)
PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)
Gene: PINX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

The method score is based on:

Property	Details
Experiments	11701125, 28255170, 15381700
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0007004 - telomere maintenance via telomerase GO:0031647 - regulation of protein stability and 2 others more... GO:0070034 - telomerase RNA binding GO:1904751 - positive regulation of protein localization to nucleolus
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	1132
Hs

1	328

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024