HitPredict

Interactor 1: CHK1 (O14757)
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
Gene: CHEK1

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	36931259, 20639859
Identification Methods	affinity chromatography technology, coimmunoprecipitation, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 476 Hs			1 247
+	Hs
		154171 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	At
		1280891 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14337_ARATH (3-244): 3.18e-142: 400: 60.25
+	At
		788672 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14333_ARATH (1-244): 4.4e-142: 400: 61.79
+	At
		965360 CIPKC_ARATH (5-476): 7.23e-158: 458: 25.42		14332_ARATH (4-244): 1.39e-141: 398: 61.32
+	Hs
		154139 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		154163 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		154135 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Sp
		710360 CHK1_SCHPO (9-462): 5.11e-130: 387: 27.55		RAD24_SCHPO (3-247): 8.91e-135: 381: 60.82
+	Hs
		154140 CHK1_HUMAN (1-476): 3.68e-166: 478: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16