HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	9325248, 32313199, 11940602, 19343040, 23142077
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 480
+	Hs
		121422 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00
+	Hs
		154364 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85
+	Hs
		121484 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85
+	Hs
		154397 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41
+	Mm
		292705 TR10B_MOUSE (1-435): 5.71e-95: 292: 34.17		CASP8_MOUSE (6-479): 1.68e-146: 429: 24.60
+	Hs
		121517 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41
+	Hs
		584406 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85
+	Hs
		181588 TNR6_HUMAN (52-184): 2.49e-31: 124: 25.53		CFLAR_HUMAN (1-480): 5.94e-178: 509: 100.00
+	Hs
		584446 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41
+	Hs
		1059370 TNR27_HUMAN (63-347): 2.72e-35: 134: 14.75		CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85
+	Hs
		632279 TNR6_HUMAN (52-184): 2.49e-31: 124: 25.53		CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85
+	Mm
		292695 TNR6_MOUSE (61-184): 1.08e-28: 117: 24.24		CASP8_MOUSE (6-479): 1.68e-146: 429: 24.60
+	Hs
		584338 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		CASP2_HUMAN (79-479): 7.53e-101: 311: 18.71
+	Hs
		1271829 TNR27_HUMAN (63-347): 2.72e-35: 134: 14.75		CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41
+	Hs
		584355 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		CASP7_HUMAN (183-478): 3.6e-92: 283: 21.38
+	Hs
		632343 TNR6_HUMAN (52-184): 2.49e-31: 124: 25.53		CASPA_HUMAN (4-453): 5.22e-122: 368: 25.41