HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: TNR3 (P36941)
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)
Gene: LTBR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TNFR_c6~TNFR_c6
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0071260 - cellular response to mechanical stimulus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 435
+	Hs
		154307 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43
+	Hs
		154424 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		EDAR_HUMAN (10-340): 4.46e-40: 150: 14.24
+	Hs
		154311 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TNR6_HUMAN (13-169): 4.9e-34: 131: 26.63
+	Hs
		121420 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR10A_HUMAN (30-173): 4.27e-24: 106: 28.77
+	Hs
		154277 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR10C_HUMAN (2-169): 2.7e-23: 100: 21.89
+	Hs
		154399 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		TR19L_HUMAN (61-153): 1.28e-15: 80.4: 27.66
+	Hs
		121520 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		TR19L_HUMAN (61-153): 1.28e-15: 80.4: 27.66
+	Hs
		584310 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR1A_HUMAN (36-338): 1.98e-54: 189: 21.43
+	Hs
		584311 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR1B_HUMAN (9-231): 1.16e-44: 163: 30.84
+	Hs
		1274098 TNR25_HUMAN (58-424): 4.73e-60: 203: 19.24		TNR25_HUMAN (40-336): 8.43e-43: 157: 17.32
+	Hs
		584316 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		TNR6_HUMAN (13-169): 4.9e-34: 131: 26.63
+	Hs
		267337 TNR16_HUMAN (53-393): 6.19e-51: 179: 16.30		TNR21_HUMAN (50-229): 2.6e-42: 160: 26.11
+	Hs
		267332 TNR21_HUMAN (52-336): 1.13e-43: 164: 14.63		TNR21_HUMAN (50-229): 2.6e-42: 160: 26.11
+	Hs
		639548 TNR5_HUMAN (44-297): 3.52e-40: 146: 16.79		TNR5_HUMAN (15-287): 7.61e-52: 177: 26.01
+	Hs
		436603 TNR16_HUMAN (53-393): 6.19e-51: 179: 16.30		TNR16_HUMAN (26-129): 5.27e-16: 81.5: 22.64
+	Rn
		421806 TNR16_RAT (53-393): 2.11e-50: 177: 16.30		TNR16_RAT (26-129): 4.99e-16: 81.5: 24.53