HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 25551360, 19432816, 11094155, 16554480, 9311998, 10549288, 22585859, 21822306, 10894161, 16227629, 20103630, 19427028, 10894160, 20097879, 22266862, 21525171, 21459798, 10542098, 23678861
Identification Methods affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0043065 - positive regulation of apoptotic process
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0045569 - TRAIL binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 440
Hs

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Last updated: 15 Jul 2024