HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	15659383, 31871319
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 193
+	Hs
		154338 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		154295 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		154343 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		154333 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		154300 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		154332 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		154336 TR10B_HUMAN (1-440): 4.52e-132: 389: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		121467 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		121470 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		121431 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		121472 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		121466 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		121436 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		121464 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		121469 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120192 TR10A_HUMAN (5-440): 4.6e-108: 329: 50.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		584359 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		584368 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436154 TNR1A_HUMAN (46-422): 1.95e-65: 218: 19.72		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		267336 TNR21_HUMAN (52-336): 1.13e-43: 164: 14.63		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71