HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.640

The method score is based on:

Property Details
Experiments 32313199, 22585859, 23142077
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0007250 - activation of NF-kappaB-inducing kinase activity
GO:0034976 - response to endoplasmic reticulum stress
GO:0042981 - regulation of apoptotic process
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 440
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024