HitPredict

Interactor 1: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.762

The method score is based on:

Property Details
Experiments 26186194, 28514442, 28972304, 19432816, 31443721, 9325248, 32313199, 33961781, 11940602, 19343040, 15388581, 23142077, 15659383, 17047155, 22421964, 20103630, 25043603
Identification Methods affinity chromatography technology, enzymatic study, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006915 - apoptotic process
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462 - TRAIL-activated apoptotic signaling pathway
GO:0043065 - positive regulation of apoptotic process
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 1 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024