HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0005634 - nucleus GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 323
+	Hs
		738023 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		724689 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		906584 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Sc
		696346 NDC80_YEAST (58-623): 9.22e-31: 130: 19.40		PP12_YEAST (3-304): 0: 550: 85.76
+	Hs
		738064 MYO5C_HUMAN (194-519): 6.56e-13: 74.5: 9.71		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		724746 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Mm
		906240 MYH6_MOUSE (181-583): 1.54e-15: 82.9: 10.95		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		906052 MY18A_HUMAN (210-628): 6.72e-15: 80.8: 14.45		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		528366 MYH6_HUMAN (243-632): 9.68e-15: 80.2: 14.50		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		906154 MYO5C_HUMAN (194-519): 6.56e-13: 74.5: 9.71		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		724747 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		906549 MY18A_HUMAN (210-628): 6.72e-15: 80.8: 14.45		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		906607 MYO5C_HUMAN (194-519): 6.56e-13: 74.5: 9.71		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		931058 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08
+	Hs
		724764 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08
+	Hs
		725131 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		PP2AB_HUMAN (8-312): 2.02e-178: 497: 46.73