HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: CEP85 (Q6P2H3)
Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)
Gene: CEP85

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0007059 - chromosome segregation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 762
+	Hs
		154986 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		CE85L_HUMAN (33-762): 5.08e-44: 172: 33.38
+	Hs
		155131 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		MYO5C_HUMAN (278-761): 3.69e-28: 124: 13.05
+	Hs
		154959 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		DCTN1_HUMAN (504-754): 1.94e-12: 73.2: 13.78
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (396-760): 3.11e-16: 85.6: 12.06
+	Hs
		725035 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYO5C_HUMAN (278-761): 3.69e-28: 124: 13.05
+	Sc
		689263 NDC80_YEAST (58-623): 9.22e-31: 130: 19.40		SP110_YEAST (400-749): 9.21e-12: 70.7: 18.38
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (390-752): 1.69e-19: 96.3: 11.97
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (104-690): 5.89e-23: 107: 10.46
+	Hs
		1137917 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MRCKA_HUMAN (390-752): 1.01e-18: 93.6: 12.47
+	Hs
		1137871 MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42		MRCKA_HUMAN (390-752): 1.01e-18: 93.6: 12.47
+	Rn
		222476 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKB_RAT (476-761): 2.47e-14: 79.6: 13.06
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (396-760): 3.11e-16: 85.6: 12.06
+	Rn
		1186812 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKB_RAT (476-761): 2.47e-14: 79.6: 13.06
+	Hs
		1268126 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MY18A_HUMAN (330-673): 4.69e-09: 62.3: 17.90
+	Mm
		93570 MYH9_MOUSE (183-642): 2.55e-18: 91.8: 11.55		DESP_MOUSE (380-749): 1.09e-10: 67.7: 15.93
+	Hs
		724810 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		ROCK1_HUMAN (179-749): 1.59e-10: 67: 12.08
+	Hs
		148460 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CTRO_HUMAN (260-622): 2.7e-09: 63.1: 14.80
+	Hs
		724943 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MY18A_HUMAN (330-673): 4.69e-09: 62.3: 17.90