HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: CEP63 (Q96MT8)
Centrosomal protein of 63 kDa (Cep63)
Gene: CEP63

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	32296183, 34079125, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 703
+	Hs
		155102 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		CP250_HUMAN (150-696): 7.75e-10: 64.8: 11.94
+	Hs
		724969 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CEP63_HUMAN (1-703): 1.84e-64: 228: 100.00
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (145-703): 1.35e-24: 112: 10.78
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (145-703): 1.35e-24: 112: 10.78
+	Hs
		725095 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		MYH10_HUMAN (145-703): 1.35e-24: 112: 10.78
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (1-520): 3.09e-20: 98.3: 12.02
+	Hs
		1268126 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Hs
		148460 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Rn
		361106 MYH6_RAT (190-583): 3.4e-15: 81.7: 10.63		MYH6_RAT (1-521): 9.79e-18: 90.4: 11.77
+	Hs
		724943 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MY18A_HUMAN (51-572): 5.91e-15: 81.2: 16.15
+	Hs
		148466 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Hs
		148461 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		CTRO_HUMAN (22-572): 2.81e-16: 85.5: 13.29
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (80-483): 2.52e-09: 62.9: 16.67
+	Rn
		222476 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKA_RAT (80-483): 2.52e-09: 62.9: 16.67
+	Hs
		724994 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CP250_HUMAN (150-696): 7.75e-10: 64.8: 11.94
+	Mm
		93570 MYH9_MOUSE (183-642): 2.55e-18: 91.8: 11.55		DESP_MOUSE (59-550): 4.18e-09: 62.5: 18.91