HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.666

Property	Details
Experiments	16189514, 29892012, 31515488
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 779
+	Hs
		154979 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1118950 TGO1_HUMAN (195-642): 2.07e-29: 127: 15.45		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		155131 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		MYO5C_HUMAN (85-502): 3.91e-13: 75.5: 11.37
+	Hs
		155149 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		EP15R_HUMAN (483-673): 1.1e-10: 67.4: 13.09
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (222-773): 1.7e-23: 109: 10.95
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (222-773): 1.7e-23: 109: 10.95
+	Hs
		1137917 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MRCKA_HUMAN (242-732): 6.78e-18: 91.3: 12.33
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (140-608): 2.17e-16: 86.3: 11.49
+	Hs
		1137871 MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42		MRCKA_HUMAN (242-732): 6.78e-18: 91.3: 12.33
+	Rn
		222476 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKB_RAT (148-603): 2.09e-15: 83.2: 10.35
+	Rn
		1186812 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKB_RAT (148-603): 2.09e-15: 83.2: 10.35
+	Hs
		728523 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		CING_HUMAN (175-776): 2.05e-17: 89.3: 9.97
+	Hs
		725035 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYO5C_HUMAN (85-502): 3.91e-13: 75.5: 11.37
+	Mm
		93570 MYH9_MOUSE (183-642): 2.55e-18: 91.8: 11.55		DESP_MOUSE (51-596): 2.35e-09: 63.5: 8.81
+	Hs
		724839 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PLEC_HUMAN (191-769): 1.21e-09: 64.3: 9.88
+	Hs
		728528 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		SMC3_HUMAN (220-710): 6.48e-09: 61.6: 14.34