HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: MTCL1 (Q9Y4B5)
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)
Gene: MTCL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0007059 - chromosome segregation GO:0008017 - microtubule binding GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 1905
+	Hs
		154908 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		MTCL2_HUMAN (52-1172): 3.52e-13: 77.4: 10.52
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04
+	Hs
		528435 MYH4_HUMAN (185-613): 1.92e-14: 79.4: 9.46		MYH8_HUMAN (849-1531): 1.11e-25: 118: 8.61
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (127-797): 1.09e-16: 89: 10.88
+	Mm
		93570 DESP_MOUSE (190-642): 1.18e-15: 83.5: 15.27		MYH9_MOUSE (163-823): 1.3e-18: 95.5: 10.98
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (127-797): 1.09e-16: 89: 10.88
+	Hs
		502901 MYH6_HUMAN (243-632): 9.68e-15: 80.2: 14.50		MYH3_HUMAN (172-837): 1.14e-17: 92.4: 13.13
+	Hs
		725095 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		MYH10_HUMAN (127-797): 1.09e-16: 89: 10.88
+	Hs
		502933 MYH4_HUMAN (185-613): 1.92e-14: 79.4: 9.46		MYH3_HUMAN (172-837): 1.14e-17: 92.4: 13.13
+	Hs
		522657 MYH4_HUMAN (185-613): 1.92e-14: 79.4: 9.46		MYH7_HUMAN (157-813): 2.43e-17: 91.3: 10.38
+	Hs
		528356 MYH6_HUMAN (243-632): 9.68e-15: 80.2: 14.50		MYH6_HUMAN (161-848): 4.68e-17: 90.1: 10.65
+	Rn
		361106 MYH6_RAT (190-583): 3.4e-15: 81.7: 10.63		MYH6_RAT (240-707): 1.2e-13: 79: 11.92
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04
+	Hs
		724839 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		PLEC_HUMAN (321-1278): 1.45e-09: 65.7: 16.15
+	Hs
		724943 MY18A_HUMAN (210-628): 6.72e-15: 80.8: 14.45		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04
+	Hs
		551596 DESP_HUMAN (214-616): 3.69e-13: 75.4: 14.63		DESP_HUMAN (294-843): 6.21e-12: 73.4: 16.70
+	Hs
		1068617 MY18A_HUMAN (210-628): 6.72e-15: 80.8: 14.45		PLEC_HUMAN (321-1278): 1.45e-09: 65.7: 16.15
+	Hs
		725035 MYO5C_HUMAN (194-519): 6.56e-13: 74.5: 9.71		MYH9_HUMAN (171-636): 9.75e-11: 69.3: 10.04