HitPredict

Interactor 1: TNPO2 (O14787)
Transportin-2 (Karyopherin beta-2b)
Gene: TNPO2

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	12384575, 35271311, 32296183, unassigned1304
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 897 Hs			1 216
+	Dm
		1373317 Q9VRV8_DROME (1-897): 0: 615: 71.46		RANL_DROME (1-210): 2.56e-93: 273: 60.48
+	Hs
		919198 TNPO1_HUMAN (2-897): 0: 625: 84.39		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784988 TNPO1_ARATH (3-895): 3.8e-169: 516: 42.90		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784992 IMB1_ARATH (9-851): 4.27e-101: 336: 15.32		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784999 IMB1_ARATH (9-851): 4.27e-101: 336: 15.32		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	At
		1210454 IMB1_ARATH (9-851): 4.27e-101: 336: 15.32		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Sc
		698781 IMB2_YEAST (2-894): 6.74e-101: 337: 30.25		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sc
		699003 IMB2_YEAST (2-894): 6.74e-101: 337: 30.25		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		874484 XPO2_HUMAN (3-896): 5.07e-90: 308: 13.52		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		178143 IPO8_HUMAN (10-847): 3.45e-88: 304: 14.44		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		919077 IMB1_HUMAN (11-871): 1.22e-86: 297: 17.83		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		312234 IPO7_HUMAN (11-850): 2.74e-78: 277: 13.25		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698945 IMB1_YEAST (12-839): 2.32e-74: 263: 14.56		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Sc
		687908 IMB3_YEAST (7-612): 1.26e-33: 141: 17.08		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Hs
		919182 IPO4_HUMAN (23-761): 3.84e-35: 146: 17.15		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		687909 IMB3_YEAST (7-612): 1.26e-33: 141: 17.08		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		127238 IPO5_HUMAN (20-627): 9.22e-15: 81.2: 10.75		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		236414 RNBP6_HUMAN (11-615): 2.76e-12: 73.1: 10.55		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94