Interactor 1: GDF8 (O14793)
Growth/differentiation factor 8 (GDF-8) (Myostatin)
Gene: MSTN

Interactor 2: GDF8 (O14793)
Growth/differentiation factor 8 (GDF-8) (Myostatin)
Gene: MSTN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.849

The method score is based on:

Property Details
Experiments 29330193, 23829672
Identification Methods molecular sieving, static light scattering, comigration in sds page, x-ray crystallography, x ray scattering, surface plasmon resonance, comigration in gel electrophoresis
Interaction Type direct interaction, covalent binding

The annotation score is based on:

Property Details
Interacting Pfam domains TGF_beta~TGF_beta, TGF_beta~TGFb_propeptide, TGFb_propeptide~TGFb_propeptide
Common GO terms GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005615 - extracellular space
GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0007517 - muscle organ development
and 27 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 375
Hs

1 375
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024