HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 1210
+	Hs
		176333 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		176447 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		155844 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		176340 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		155824 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383529 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		176382 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		155833 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Mm
		763386 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52
+	Hs
		176389 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		176345 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		412036 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51
+	Hs
		155839 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		155837 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Mm
		710126 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68
+	Hs
		412070 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37
+	Mm
		763399 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		Q8C2G0_MOUSE (716-974): 2.2e-52: 202: 37.64
+	Hs
		412075 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59
+	Mm
		536207 FGR_MOUSE (3-124): 4.13e-35: 128: 24.22		KSYK_MOUSE (718-961): 3.5e-53: 199: 42.04
+	Dm
		382221 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		EGFR_DROME (30-339): 1.78e-25: 116: 21.28