HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: PLCG2 (P16885)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Gene: PLCG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.710

Property	Details
Experiments	24642916
Identification Methods	surface plasmon resonance, pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	C2~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 1265
+	Hs
		411992 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PLCG2_HUMAN (1-1265): 0: 1276: 100.00
+	Mm
		763400 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		PLCG2_MOUSE (1-1265): 0: 1276: 94.15
+	Mm
		557351 BLK_MOUSE (5-125): 7.82e-35: 127: 25.40		PLCG2_MOUSE (1-1265): 0: 1276: 94.15
+	Hs
		562634 BLK_HUMAN (5-125): 2.91e-34: 125: 24.60		PLCG2_HUMAN (1-1265): 0: 1276: 100.00
+	Hs
		433564 LYN_HUMAN (3-125): 4.15e-33: 122: 23.26		PLCG2_HUMAN (1-1265): 0: 1276: 100.00
+	Mm
		639456 LYN_MOUSE (3-125): 3.75e-33: 122: 24.03		PLCG2_MOUSE (1-1265): 0: 1276: 94.15
+	Mm
		1208606 SHIP1_MOUSE (4-132): 5.2e-32: 120: 34.88		PLCG2_MOUSE (1-1265): 0: 1276: 94.15
+	Hs
		562638 GRB2_HUMAN (4-88): 3.18e-17: 75.9: 32.94		PLCG2_HUMAN (1-1265): 0: 1276: 100.00
+	Hs
		155832 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		412000 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		337341 ABL1_HUMAN (5-131): 2.58e-34: 127: 25.78		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		580953 ABL2_HUMAN (5-131): 3.02e-34: 126: 25.00		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Hs
		522758 SRC_HUMAN (3-125): 2.31e-33: 123: 25.58		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Mm
		1143295 SHIP1_MOUSE (4-132): 5.2e-32: 120: 34.88		PLCG1_MOUSE (11-1261): 0: 1148: 49.33
+	Hs
		580972 GRB2_HUMAN (4-88): 3.18e-17: 75.9: 32.94		PLCG1_HUMAN (11-1247): 0: 1149: 49.72
+	Mm
		1141132 GRB2_MOUSE (4-88): 3.18e-17: 75.9: 32.94		PLCG1_MOUSE (11-1261): 0: 1148: 49.33
+	Rn
		499159 GRB2_RAT (4-88): 3.18e-17: 75.9: 32.94		PLCG1_RAT (11-1247): 0: 1145: 49.56
+	Hs
		411745 LCK_HUMAN (3-127): 1.87e-34: 126: 25.19		PLCH1_HUMAN (700-1262): 2.32e-103: 363: 21.54
+	Hs
		433798 LYN_HUMAN (3-125): 4.15e-33: 122: 23.26		PLCH1_HUMAN (700-1262): 2.32e-103: 363: 21.54
+	Hs
		434024 LYN_HUMAN (3-125): 4.15e-33: 122: 23.26		PLCB1_HUMAN (837-1241): 1.26e-94: 332: 25.59