HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: SLAF6 (Q96DU3)
SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
Gene: SLAMF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	23346089, 16920955
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 332
+	Hs
		243153 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF6_HUMAN (1-332): 1.42e-70: 224: 100.00
+	Hs
		155840 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF1_HUMAN (1-313): 6.65e-63: 204: 18.68
+	Hs
		412176 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SLAF1_HUMAN (1-313): 6.65e-63: 204: 18.68
+	Hs
		243137 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF1_HUMAN (1-313): 6.65e-63: 204: 18.68
+	Hs
		155857 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF7_HUMAN (6-332): 6.95e-61: 199: 27.62
+	Hs
		176495 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Hs
		155856 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Hs
		412347 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Hs
		243155 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Hs
		155858 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF5_HUMAN (2-332): 7.51e-56: 186: 25.36
+	Hs
		411939 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD2_HUMAN (6-326): 4.55e-55: 185: 16.57
+	Mm
		991971 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		CD244_MOUSE (5-318): 1.22e-50: 174: 17.27
+	Mm
		1115123 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		SLAF1_MOUSE (2-315): 4.08e-47: 163: 18.56
+	Mm
		1061798 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		SLAF1_MOUSE (2-315): 4.08e-47: 163: 18.56
+	Mm
		192617 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF1_MOUSE (2-315): 4.08e-47: 163: 18.56
+	Mm
		763408 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SLAF1_MOUSE (2-315): 4.08e-47: 163: 18.56
+	Hs
		243157 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		LY9_HUMAN (4-277): 2.81e-44: 162: 28.01
+	Mm
		192616 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF7_MOUSE (4-332): 1.12e-41: 149: 26.59
+	Hs
		155860 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ROBO1_HUMAN (127-299): 5.06e-14: 75.3: 9.60
+	Hs
		243129 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD22_HUMAN (27-319): 1.21e-13: 73.7: 11.46