HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: SLAF7 (Q9NQ25)
SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
Gene: SLAMF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	24642916
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002250 - adaptive immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 335
+	Mm
		192616 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF7_MOUSE (1-335): 7.13e-61: 199: 48.81
+	Hs
		155840 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF1_HUMAN (3-325): 4.68e-59: 195: 18.75
+	Hs
		412176 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SLAF1_HUMAN (3-325): 4.68e-59: 195: 18.75
+	Hs
		243137 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF1_HUMAN (3-325): 4.68e-59: 195: 18.75
+	Hs
		176495 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Hs
		155856 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Hs
		412347 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Hs
		243155 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD244_HUMAN (1-334): 1.81e-53: 181: 19.72
+	Mm
		991971 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		CD244_MOUSE (1-334): 1.92e-49: 171: 15.84
+	Hs
		155858 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF5_HUMAN (1-335): 1.9e-50: 172: 29.10
+	Mm
		1115123 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		SLAF1_MOUSE (3-325): 6.34e-46: 161: 18.52
+	Hs
		155852 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SLAF6_HUMAN (9-335): 1.13e-47: 165: 27.67
+	Mm
		1061798 Q149T1_MOUSE (1-132): 5.45e-41: 134: 65.15		SLAF1_MOUSE (3-325): 6.34e-46: 161: 18.52
+	Mm
		192617 SH21B_MOUSE (1-132): 6.93e-41: 134: 65.15		SLAF1_MOUSE (3-325): 6.34e-46: 161: 18.52
+	Hs
		243153 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		SLAF6_HUMAN (9-335): 1.13e-47: 165: 27.67
+	Hs
		243157 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		LY9_HUMAN (19-298): 1.41e-44: 163: 26.06
+	Mm
		763408 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SLAF1_MOUSE (3-325): 6.34e-46: 161: 18.52
+	Hs
		411939 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		CD2_HUMAN (4-323): 2.41e-42: 151: 17.16
+	Hs
		155860 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ROBO1_HUMAN (125-317): 3.99e-20: 93.4: 11.43
+	Hs
		243129 SH21A_HUMAN (6-113): 2.35e-38: 127: 44.44		CD22_HUMAN (11-224): 7.17e-11: 65.2: 16.59