HitPredict

Interactor 1: RPC1 (O14802)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Gene: POLR3A

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16055720
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045087 - innate immune response
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 1319
+	Hs
		624804 RPB1_HUMAN (2-1382): 0: 1534: 32.10		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Sc
		375492 RPB1_YEAST (1-1381): 0: 1438: 31.80		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Hs
		625031 RPB1_HUMAN (2-1382): 0: 1534: 32.10		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		125161 RPB1_HUMAN (2-1382): 0: 1534: 32.10		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Mm
		444988 RPB1_MOUSE (2-1382): 0: 1534: 32.10		WWP2_MOUSE (381-669): 4.39e-33: 141: 13.37
+	Hs
		624998 RPB1_HUMAN (2-1382): 0: 1534: 32.10		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		625052 RPB1_HUMAN (2-1382): 0: 1534: 32.10		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Sc
		375403 RPB1_YEAST (1-1381): 0: 1438: 31.80		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41
+	Sc
		501407 RPA1_YEAST (7-146): 6.55e-36: 151: 22.86		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42