HitPredict

Interactor 1: RASM (O14807)
Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
Gene: MRAS

Interactor 2: RPGF5 (Q92565)
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)
Gene: RAPGEF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	10934204
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0030742 - GTP-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 208 Hs			1 580
+	Hs
		919657 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF5_HUMAN (1-580): 0: 597: 100.00
+	Hs
		919656 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF4_HUMAN (60-579): 4.62e-177: 529: 46.39
+	Hs
		156094 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		313169 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		313171 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		156099 RASM_HUMAN (1-208): 1.97e-98: 285: 100.00		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		905420 RRAS2_HUMAN (14-194): 8.41e-64: 197: 60.00		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		897883 RAP1B_HUMAN (14-190): 1.56e-57: 181: 51.12		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		919618 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		1021728 RIT2_HUMAN (14-189): 2.78e-55: 176: 50.84		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		1021726 RIT1_HUMAN (14-191): 1.2e-54: 175: 51.12		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		919653 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		919687 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF2_HUMAN (182-578): 7.88e-100: 333: 24.51
+	Dm
		442976 RAP1_DROME (14-175): 2.88e-57: 180: 54.32		Q9VMF3_DROME (214-563): 2.5e-88: 300: 30.28
+	Hs
		919625 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		992491 RIT2_HUMAN (14-189): 2.78e-55: 176: 50.84		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Ce
		1089983 RAP1_CAEEL (11-208): 2.42e-85: 251: 46.47		Q19770_CAEEL (294-579): 2.05e-63: 221: 23.13
+	Hs
		919645 RAP1A_HUMAN (14-180): 3.95e-57: 180: 53.57		RGDSR_HUMAN (116-578): 3.04e-91: 290: 12.17
+	Sc
		350755 RAS1_YEAST (14-176): 1.24e-54: 177: 58.90		CDC25_YEAST (334-579): 2.72e-66: 236: 23.41
+	Sc
		350781 RAS2_YEAST (10-178): 1.09e-52: 173: 55.62		CDC25_YEAST (334-579): 2.72e-66: 236: 23.41