HitPredict

Interactor 1: PSA7 (O14818)
Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)
Gene: PSMA7

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	36357363, 35256949, 23503661, 15987638
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 465
+	Hs
		228119 PSMA8_HUMAN (3-230): 3.5e-98: 288: 82.91		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226590 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227023 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226564 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226565 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		637475 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58
+	Hs
		893742 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36
+	Hs
		637539 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36
+	Hs
		156205 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		286452 PSA6B_ARATH (2-236): 3.21e-104: 303: 35.98		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475369 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		286449 PSA6A_ARATH (2-236): 4.28e-94: 278: 36.82		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475547 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475358 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		189234 PSA7B_ARATH (3-229): 3.38e-93: 275: 68.12		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		672527 PSA7A_ARATH (3-229): 3.17e-92: 273: 68.56		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		286456 PSA4A_ARATH (3-242): 2.64e-91: 271: 34.27		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		188696 PSA2A_ARATH (3-233): 2.08e-91: 270: 37.77		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		474930 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	At
		1091773 PSA2B_ARATH (3-233): 5.26e-52: 170: 38.14		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17