HitPredict

Interactor 1: PSA7 (O14818)
Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)
Gene: PSMA7

Interactor 2: PSMA8 (Q8TAA3)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
Gene: PSMA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 256
+	Hs
		156169 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA7_HUMAN (5-238): 2.46e-101: 296: 82.91
+	Zm
		85792 C0PFK3_MAIZE (2-236): 1.62e-105: 307: 36.82		C0PFK3_MAIZE (2-243): 2.18e-94: 278: 32.52
+	Hs
		156230 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		156266 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA6_HUMAN (2-243): 1.76e-91: 271: 29.27
+	Hs
		156223 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		156226 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Ss
		94582 F1SBA5_PIG (3-226): 2.91e-102: 298: 86.16		F2Z5L7_PIG (3-249): 1.17e-89: 267: 31.08
+	Dm
		611647 PSA5_DROME (3-233): 1.88e-95: 281: 34.45		PSA71_DROME (1-237): 2.13e-94: 279: 69.20
+	Hs
		656276 PSMA8_HUMAN (3-230): 3.5e-98: 288: 82.91		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Ce
		1278559 PSA7_CAEEL (3-230): 5.05e-95: 280: 63.64		PSA7_CAEEL (3-240): 1.92e-93: 277: 57.26
+	Hs
		637494 PSMA8_HUMAN (3-230): 3.5e-98: 288: 82.91		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Sp
		1013784 PSA5_SCHPO (3-235): 3.47e-95: 280: 38.49		PSA4_SCHPO (3-255): 8.15e-91: 270: 53.33
+	Hs
		656149 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSA5_HUMAN (3-240): 2.51e-91: 271: 36.74
+	Hs
		637325 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSA1_HUMAN (3-249): 1.17e-89: 267: 31.08
+	Hs
		638067 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSA4_HUMAN (1-237): 2.99e-89: 266: 34.84
+	Hs
		156224 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51
+	Hs
		637719 PSMA8_HUMAN (3-230): 3.5e-98: 288: 82.91		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51
+	Dm
		771303 PSA5_DROME (3-233): 1.88e-95: 281: 34.45		PSA2_DROME (4-222): 1.8e-47: 159: 40.27
+	Hs
		637631 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSA2_HUMAN (1-240): 6.58e-46: 155: 39.51