HitPredict

Interactor 1: PSA7 (O14818)
Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)
Gene: PSMA7

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 953
+	Hs
		656297 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		893734 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		637529 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		689 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		699 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Hs
		685 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		1278636 PSA5_DROME (3-233): 1.88e-95: 281: 34.45		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		611652 PSA71_DROME (3-229): 3.48e-94: 278: 68.72		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Hs
		686 PSA2_HUMAN (3-232): 1.61e-48: 161: 37.87		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Sp
		251850 PSA4_SCHPO (2-248): 7.38e-93: 275: 53.23		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	Sc
		693311 PSA4_YEAST (2-232): 1.85e-93: 276: 58.55		RPN2_YEAST (2-953): 0: 984: 40.26
+	Hs
		156281 PSA7_HUMAN (1-230): 7.2e-104: 302: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		656214 PSA5_HUMAN (3-232): 1.08e-94: 279: 35.32		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		893662 PSA6_HUMAN (2-236): 1.66e-93: 276: 32.64		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		637407 PSA1_HUMAN (3-244): 5.16e-93: 275: 32.11		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		1278652 PSA5_DROME (3-233): 1.88e-95: 281: 34.45		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		611672 PSA71_DROME (3-229): 3.48e-94: 278: 68.72		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		953217 PSA5_SCHPO (3-235): 3.47e-95: 280: 38.49		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sp
		953206 PSA4_SCHPO (2-248): 7.38e-93: 275: 53.23		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sc
		753833 PSA4_YEAST (2-232): 1.85e-93: 276: 58.55		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96