HitPredict

Interactor 1: FFAR1 (O14842)
Free fatty acid receptor 1 (G-protein coupled receptor 40)
Gene: FFAR1

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 300 Hs			1 1154
+	Hs
		616748 APJ_HUMAN (4-299): 4.6e-67: 215: 19.68		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		616777 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		616762 LPAR6_HUMAN (6-280): 3.69e-59: 194: 19.52		JAK1_HUMAN (1-1154): 0: 1035: 100.00
+	Hs
		238391 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Rn
		626617 AGTRA_RAT (2-292): 1.15e-58: 193: 19.41		JAK2_RAT (33-1153): 0: 782: 41.54
+	Hs
		428898 ADRB2_HUMAN (10-292): 1.55e-67: 217: 15.67		SRC_HUMAN (868-1151): 7e-99: 326: 31.23
+	Hs
		433268 CCR1_HUMAN (3-280): 8.74e-69: 219: 21.53		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		122341 PAR3_HUMAN (3-281): 8.48e-64: 207: 20.42		ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72
+	Hs
		122343 PAR3_HUMAN (3-281): 8.48e-64: 207: 20.42		SRC_HUMAN (868-1151): 7e-99: 326: 31.23
+	Hs
		522832 P2RY2_HUMAN (2-281): 5.23e-63: 205: 21.89		SRC_HUMAN (868-1151): 7e-99: 326: 31.23
+	Mm
		403428 5HT4R_MOUSE (2-293): 3.41e-64: 208: 13.79		SRC_MOUSE (868-1151): 1.36e-97: 322: 30.88
+	Hs
		156776 FFAR1_HUMAN (1-300): 1.82e-64: 206: 100.00		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Rn
		706745 OPRM_RAT (3-300): 1.13e-62: 204: 15.91		SRC_RAT (868-1151): 1.4e-97: 322: 30.88
+	Hs
		122342 PAR3_HUMAN (3-281): 8.48e-64: 207: 20.42		FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74
+	Hs
		846452 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		BLK_HUMAN (853-1152): 7.51e-90: 300: 28.15
+	Hs
		669153 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		854164 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01
+	Hs
		669140 LPAR6_HUMAN (6-280): 3.69e-59: 194: 19.52		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		796464 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		ZAP70_HUMAN (614-841): 8.24e-17: 87.4: 28.75
+	Hs
		895632 CXCR4_HUMAN (3-280): 4.27e-65: 209: 20.69		NTRK3_HUMAN (578-853): 5.4e-14: 79: 26.40