HitPredict

Interactor 1: BACH1 (O14867)
Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303)
Gene: BACH1

Interactor 2: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_Maf
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 508
+	Hs
		157176 BACH1_HUMAN (1-736): 0: 558: 100.00		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		157172 BACH1_HUMAN (1-736): 0: 558: 100.00		ATF2_HUMAN (9-503): 1.72e-64: 219: 33.87
+	Hs
		973637 BACH2_HUMAN (1-736): 1.68e-129: 406: 29.07		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		568278 BACH2_HUMAN (1-736): 1.68e-129: 406: 29.07		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		547848 BACH2_HUMAN (1-736): 1.68e-129: 406: 29.07		ATF2_HUMAN (9-503): 1.72e-64: 219: 33.87
+	Hs
		402445 BACH2_HUMAN (1-736): 1.68e-129: 406: 29.07		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		568264 NFE2_HUMAN (513-624): 4.39e-42: 159: 43.36		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		568262 NF2L1_HUMAN (524-624): 2.43e-18: 91.7: 47.53		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		568249 BCL6_HUMAN (16-127): 3.15e-13: 75.1: 38.05		ATF7_HUMAN (10-505): 4.77e-72: 238: 36.18
+	Hs
		51224 ZBT7C_HUMAN (1-127): 6.19e-42: 163: 31.25		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		579308 NF2L3_HUMAN (509-663): 5.02e-43: 168: 31.71		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Hs
		579268 NFE2_HUMAN (513-624): 4.39e-42: 159: 43.36		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Hs
		401999 NF2L1_HUMAN (524-624): 2.43e-18: 91.7: 47.53		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		568072 BCL6_HUMAN (16-127): 3.15e-13: 75.1: 38.05		JUND_HUMAN (173-450): 4.53e-29: 119: 14.95
+	Hs
		401568 BCL6_HUMAN (16-127): 3.15e-13: 75.1: 38.05		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		579263 NF2L1_HUMAN (524-624): 2.43e-18: 91.7: 47.53		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Hs
		402074 NF2L2_HUMAN (524-620): 7.71e-13: 73.9: 42.27		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		566732 BCL6_HUMAN (16-127): 3.15e-13: 75.1: 38.05		JUNB_HUMAN (191-447): 3.94e-24: 105: 15.14
+	Hs
		579266 NF2L2_HUMAN (524-620): 7.71e-13: 73.9: 42.27		ATF4_HUMAN (198-437): 6.21e-23: 101: 15.29
+	Mm
		542941 NF2L2_MOUSE (524-617): 5.67e-12: 70.9: 41.49		JUND_MOUSE (177-452): 1.57e-23: 103: 16.56