HitPredict

Interactor 1: GIPC1 (O14908)
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)
Gene: GIPC1

Interactor 2: DP13B (Q8NEU8)
DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
Gene: APPL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29467281, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0016020 - membrane GO:0031410 - cytoplasmic vesicle GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 333 Hs			1 664
+	Hs
		158248 GIPC1_HUMAN (1-333): 0: 510: 100.00		DP13A_HUMAN (1-664): 0: 671: 49.58
+	Hs
		1257225 GIPC2_HUMAN (1-329): 2.12e-159: 449: 61.40		DP13A_HUMAN (1-664): 0: 671: 49.58
+	Hs
		158229 GIPC1_HUMAN (1-333): 0: 510: 100.00		DOCK9_HUMAN (198-522): 4.09e-56: 209: 15.76
+	Hs
		158196 GIPC1_HUMAN (1-333): 0: 510: 100.00		PKHA7_HUMAN (209-416): 7.65e-35: 143: 12.65
+	Hs
		158232 GIPC1_HUMAN (1-333): 0: 510: 100.00		PKHA4_HUMAN (245-428): 9.68e-13: 73.7: 14.36