HitPredict

Interactor 1: LIN7A (O14910)
Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)
Gene: LIN7A

Interactor 2: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	24366813, 14960569, 32296183, 25416956, 32707033, 16688213, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	L27~L27, Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0016323 - basolateral plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 233 Hs			1 926
+	Mm
		251089 LIN7B_MOUSE (18-217): 8.75e-52: 168: 77.00		CSKP_MOUSE (1-926): 0: 973: 99.89
+	Hs
		159269 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		CSKP_HUMAN (1-926): 0: 973: 100.00
+	Mm
		251090 LIN7C_MOUSE (18-211): 1.25e-50: 165: 79.38		CSKP_MOUSE (1-926): 0: 973: 99.89
+	Hs
		158282 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27
+	Hs
		158279 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP3_HUMAN (341-925): 8.25e-150: 456: 28.21
+	Hs
		158294 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84
+	Hs
		158304 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		PALS2_HUMAN (347-926): 1.42e-149: 454: 37.65
+	Hs
		158277 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91
+	Hs
		158271 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		DLG4_HUMAN (402-922): 1.14e-145: 451: 22.56
+	Hs
		158288 LIN7A_HUMAN (1-233): 1.49e-59: 189: 100.00		MPP7_HUMAN (354-926): 1.78e-145: 445: 30.81
+	Hs
		1050415 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27
+	Hs
		1032760 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP3_HUMAN (341-925): 8.25e-150: 456: 28.21
+	Hs
		1232501 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84
+	Hs
		1334778 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		PALS2_HUMAN (347-926): 1.42e-149: 454: 37.65
+	Mm
		292491 LIN7C_MOUSE (18-211): 1.25e-50: 165: 79.38		DLG1_MOUSE (405-923): 1.81e-145: 456: 22.06
+	Mm
		292498 LIN7C_MOUSE (18-211): 1.25e-50: 165: 79.38		PALS1_MOUSE (361-925): 1.68e-148: 456: 28.01
+	Hs
		1021563 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		DLG1_HUMAN (405-923): 2.05e-144: 453: 21.91
+	Hs
		942382 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		DLG4_HUMAN (402-922): 1.14e-145: 451: 22.56
+	Rn
		677810 LIN7B_RAT (18-214): 2.15e-51: 167: 78.17		DLG4_RAT (402-922): 3.56e-145: 449: 22.56
+	Hs
		1132892 LIN7B_HUMAN (18-214): 2.73e-51: 167: 78.17		MPP7_HUMAN (354-926): 1.78e-145: 445: 30.81