HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.639

The method score is based on:

Property Details
Experiments 19196987, 19883646
Identification Methods enzymatic study, protein kinase assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0045893 - positive regulation of DNA-templated transcription
and 2 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 756
Hs

1 393
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024