HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	33961781, 35271311, 21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 457
+	Hs
		158449 IKKB_HUMAN (1-756): 0: 662: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		167538 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1034848 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		625378 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1034968 MARK4_HUMAN (12-337): 2.64e-90: 301: 26.52		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		568651 KAPCA_HUMAN (4-283): 2.67e-90: 288: 27.66		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		684793 Q59GT1_HUMAN (1-702): 3.34e-167: 501: 51.34		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		684792 Q59GL9_HUMAN (67-517): 2.65e-142: 428: 97.56		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1012427 M3K5_HUMAN (14-657): 9.04e-137: 439: 20.00		Q0VDC6_HUMAN (151-247): 5.97e-21: 90.6: 26.73
+	Hs
		609666 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		609664 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		684710 IKKE_HUMAN (15-725): 1.15e-127: 398: 20.08		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		685087 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		568664 KAPCA_HUMAN (4-283): 2.67e-90: 288: 27.66		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		118692 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		609671 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Dm
		1179500 Q8MQJ7_DROME (15-222): 2.05e-26: 117: 33.03		Q7K3D4_DROME (3-148): 5.36e-22: 99.5: 23.31
+	Hs
		609649 KAPCG_HUMAN (4-281): 4.07e-24: 106: 29.18		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62