HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 21455180, 25852190, 25400026, 26500060, 28249776, 27426725, 30404796, 23016877, 11864612, 31145594, 11971985, 11057907, 35271311, 36736316, 36894068, 36916940, 19820708, 20932476, 19815509, 21903422 and 78 others

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Identification Methods affinity chromatography technology, pull down, biochemical, enzymatic study, x-ray crystallography, unspecified method, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation and 4 others

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Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains IKKbetaNEMObind~NEMO
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006954 - inflammatory response
GO:0007249 - canonical NF-kappaB signal transduction
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 756
Hs

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Last updated: 15 Jul 2024