HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: BRE1B (O75150)
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
Gene: RNF40

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12121982
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 1001
+	At
		639386 UBC1_ARATH (3-147): 2.99e-65: 197: 26.03		BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12
+	At
		790156 UBC2_ARATH (3-147): 2.4e-65: 197: 26.71		BRE1A_ARATH (497-1000): 3.93e-99: 334: 23.12
+	Hs
		256237 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00
+	Hs
		256229 UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01		BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00
+	Hs
		256227 UBE2A_HUMAN (3-147): 7.09e-65: 196: 30.14		BRE1B_HUMAN (1-1001): 5.92e-75: 268: 100.00
+	Hs
		919748 UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58		BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49
+	Hs
		851821 UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01		BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49
+	Hs
		932532 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49
+	Hs
		829017 UBE2A_HUMAN (3-147): 7.09e-65: 196: 30.14		BRE1A_HUMAN (1-1000): 8.12e-65: 238: 56.49
+	Ce
		712245 UBC2_CAEEL (2-149): 4.13e-75: 222: 37.58		BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44
+	At
		639387 UBC1_ARATH (3-147): 2.99e-65: 197: 26.03		BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39
+	At
		790157 UBC2_ARATH (3-147): 2.4e-65: 197: 26.71		BRE1B_ARATH (38-843): 1.3e-15: 83.9: 12.39
+	Ce
		712246 UBC1_CAEEL (3-146): 1.04e-65: 199: 30.35		BRE1_CAEEL (25-799): 1.9e-14: 79.9: 15.44
+	Hs
		148663 UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26		CTRO_HUMAN (248-944): 2.51e-10: 67.2: 14.91